Ko nga hua mai i te whakamatautau i te wahanga2 e tautoko ana i te whakaaro ko te whakahaere i raro i te kiri o te IFN-β mo te maimoatanga o COVID-19 ka piki ake te tere o te whakaora me te whakaiti i te mate..
Ko te ahuatanga whakamiharo i whakaatuhia e te mate urutaru COVID-19 kua whakamanahia ki te tirotiro i nga huarahi rereke mo te maimoatanga o nga keehi COVID-19 kino. He maha nga raau taero hou kei te whakamatautauhia, kei te whakamahia ano nga rongoa o mua. Corticosteroids kua kitea kua whai hua. Kei te whakamahia te rongoa Interferon mo nga mate huaketo penei i te mate kakā. Ka taea te whakamahi IFN ki te SARS CoV-2 i roto i te COVID-19?
I roto i nga whakamatautau o mua, i kitea e te IFN te whai hua ki te SARS CoV me MMS wheori. I te Hūrae 2020, ko te whakahaerenga o Interferon-β na roto i te nebulization (ara. pulmonary inhalation) i puta te korero ki te whakaatu i nga hua pai mo te rongoa i nga keehi COVID-19 kino i runga i nga raraunga mai i te waahanga tuarua o nga whakamatautau haumanu. 1,2.
Inaianei, ko te purongo hou e pa ana ki nga raraunga mai i te waahanga tuarua o nga whakamatautau haumanu i whakahaerehia i runga i nga turoro 2 me COVID-112 i te hohipera i Pitié-Salpêtrière i Paris, France e kii ana ko te whakahaeretanga o te IFN-β ma te ara i raro i te kiri ka piki ake te tere whakaora me te whakaheke i te mate i roto i te COVID-19 take 3.
Ko nga Interferon (IFN) he pūmua i hunahia e nga pūtau kaihautu hei whakautu ki nga mate huaketo hei tohu ki etahi atu o nga pūtau mo te noho mai o te huaketo. Ko te urupare mumura nui i etahi o nga turoro COVID-19 ka kitea he hononga ki te urupare IFN-1 ngoikore me te aukati. IFN-β hunanga. Kei te whakamahia i roto i China ki te rongoa i te pneumonia viral na te SARS CoV engari kaore i te paerewatia te whakamahinga 4.
Ko te whakamatautau haumanu tuatoru mo te whakamahi i nga Interferon (IFN) ki te rongoa i nga turoro COVID-3 kei te haere tonu. Ko te whakaaetanga ka whakawhirinaki mehemea kei roto nga hua whakamutunga i roto i te awhe e whakaaetia ana e nga kaiwhakahaere.
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Rauemi:
- NHS 2020. Panui- Ko te raau taero e mau ana ka aukati i nga turoro COVID-19 ki te kino haere i roto i te whakamatautauranga o Southampton. I whakairihia i te 20 o Hurae 2020. Kei runga ipurangi kei https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/News-and-updates/Articles/Inhaled-drug-prevents-COVID-19-patients-getting-worse-in-Southampton-trial.aspx I totoro i te 12 o Pepuere 2021.
- Monk PD., Marsden RJ., Tear VJ., et al., 2020. Te haumaru me te whai huatanga o te interferon beta-1a (SNG001) kua werohia mo te maimoatanga o te mate SARS-CoV-2: he matapōkeretia, he matapo-rua, he placebo- whakahaeretia, wahanga 2 whakamatautau. The Lancet Respiratory Medicine, Kei runga ipurangi 12 Noema 2020. DOI: https://doi.org/10.1016/S2213-2600(20)30511-7
- Dorgham K., Neumann AU., et al 2021. Ma te whakaaro ki te rongoa Interferon-β whaiaro mo COVID-19. Antimicrobial Agents Chemotherapy. I whakairihia ki runga ipurangi 8 Hui-tanguru 2021. DOI: https://doi.org/10.1128/AAC.00065-21
- Mary A., Hénaut L., Macq PY., et al 2020. Rationale for COVID-19 Treatment by Nebulized Interferon-β-1b–Literature Review and Personal Preliminary Experience. Frontiers in Pharmacology., 30 Noema 2020. DOI:https://doi.org/10.3389/fphar.2020.592543.
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