Nuvaxovid & Covovax: te 10th & 9th COVID-19 kano kano i roto i te Rarangi Whakamahi ohorere a WHO

Whai muri i te aromatawai me te whakaaetanga a te European Medicines Agency (EMA), kua tukuna e WHO he rarangi whakamahi ohorere (EUL) mo Nuvaxovid i te 21 Hakihea 2021. I mua ake i te 17 Hakihea 2021, te WHO kua tukuna he rarangi whakamahi ohorere (EUL) mo Covovax.  

Ko Covovax me Nuvaxoid ka noho hei 9^th ko 10^th Covid-19 nga kano i roto i te rarangi whakamahi ohorere a WHO.  

Ko Nuvaxovid raua ko Covovax nga kano he waeine pūmua nga kano, me te whakamahi matūriki nano. Ka mahia enei ma te hangarau nanoparticle recombinant ki te whakaputa antigen i ahu mai i te coronavirus spike (S) pūmua me te whakauru i te saponin-based Matrix-M adjuvant hei whakarei ake i te urupare aukati me te whakaongaonga i nga taumata teitei o te aukati i nga antibodies.  

Ko enei e rua nga kano kei roto i te antigen pūmua kua purea e kore e taea te tukurua, e kore e puta te mate COVID-19.  

Ka hiahiatia e Nuvaxovid & Covovax kia rua nga pota, ka noho pumau ki te 2 ki te 8 °C te pāmahana whakamatao. 

I whakawhanakehia a Nuvaxovid e Novavax, Inc., he kamupene hangarau koiora o Amerika kei Maryland. Koia te hua taketake mo Covovax.    

I whakawhanakehia a Covovax e Novavax me te Coalition for Epidemic Preparedness Innovations (CEPI) ka hangaia e te Serum Institute of India (SII) i raro i te raihana mai i Novavax. He wahanga tenei o te kopaki whakaurunga COVAX, e whakanui ana i nga mahi e haere tonu ana ki te wero kano kano kano tangata ki roto i nga waahi kaaiti rawa.  

He rite a Covovax me Nuvaxoid ki a Cuba's Soberana 02 me Abdala i roto i te mahi kano kano i te pūmua ki te COVID-19 engari ko Cuba. nga kano te whakamahi motuhake i te rohe RBD (rohe here kaiawhina) o te pūmua koikoi, te kawenga mo te urunga o te huaketo ki roto i nga pūtau tangata i te wa e whaaia ana e Nuvaxovid & Covovax te pūmua coronavirus spike (S).  

Ka rite ki a Cuba nga kano, He painga ano a Nuvaxovid & Covovax ki te noho pumau i te 2-8° C ka taea te whakarite ngawari ki te hanga kano kano hou ki nga riaka rereke.  

Ko te COVID-19 kua whakahuahia ake nei nga kano He tino rerekee mai i te COVID-19 nga kano kei te whakamahia inaianei. Ahakoa ko nga kano kano mRNA (i hangaia e Pfizer/BioNTech me Moderna) e kawe ana i nga korero mo te whakaatu i te antigen pūmua viral i roto i nga pūtau tangata, adenovirus vector-based nga kano (pērā i a Oxford/AstraZeneca's ChAdOx1 nCoV-2019 me Janssen's) e whakamahi ana i te adenovirus i hangaia i roto i te ira hei kawe hei kawe i te ira pūmua o te coronavirus hou e whakaatuhia ana i roto i nga pūtau tangata e mahi ana hei antigen mo te whanaketanga kaha o te mate. I tua atu, he utu nui nga kano kano mRNA, he take mekameka tuku matao i te wa e pa ana nga kano kano adenovirus-vector ki nga paanga onge o te toto toto.  

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Rauemi:  

1. WHO 2021. Karere - Ka whakarārangihia e WHO te kano kano COVID-10 mo te whakamahi ohorere: Nuvaxovid. I whakairihia i te 19 Hakihea 21, Kei runga ipurangi i https://www.who.int/news/item/21-12-2021-who-lists-10th-covid-19-vaccine-for-emergency-use-nuvaxovid  
2. EMA 2021. News - E taunaki ana a EMA ki a Nuvaxovid mo te whakamanatanga i roto i te EU, I tukuna 20/12/2021. Kei runga ipurangi kei https://www.ema.europa.eu/en/news/ema-recommends-nuvaxovid-authorisation-eu  
3. WHO 2021. Karere - Ka whakarārangihia e WHO te kano kano COVID-9 mo te whakamahi ohorere me te whai ki te whakapiki ake i te uru ki te kano kano ki nga whenua iti-moni. I whakairihia te 19 Hakihea 17. Kei runga ipurangi kei https://www.who.int/news/item/17-12-2021-who-lists-9th-covid-19-vaccine-for-emergency-use-with-aim-to-increase-access-to-vaccination-in-lower-income-countries  
4. Tian, ​​JH., Patel, N., Haupt, R. et al. SARS-CoV-2 spike glycoprotein kaitono kano kano NVX-CoV2373 immunogenicity i roto i nga pepi me te whakamarumaru ki nga kiore. Nat Commun 12, 372 (2021). https://doi.org/10.1038/s41467-020-20653-8  
5. Khan S., me Dhama K. 2021. Te mahi a Inia i roto i te kano kano kano COVID-19. Journal of Travel Medicine, Volume 28, Issue 7, October 2021, taab064, Published: 16 April 2021. DOI: https://doi.org/10.1093/jtm/taab064  
6. Soni R., 2021.Soberana 02 me Abdala: Ko nga Kano Kano Kano Poroteina tuatahi o te Ao ki te COVID-19. Pūtaiao Pākehā. I whakairihia i te 30 o Whiringa-a-rangi 2021. Kei runga ipurangi kei http://scientificeuropean.co.uk/covid-19/soberana-02-and-abdala-worlds-first-protein-conjugate-vaccines-against-covid-19/  
7. Prasad U. 2021. Momo Kano Kano COVID-19 i roto i te Puka: Tera pea tetahi mea he? Pūtaiao Pākehā. I whakairihia i te 20 o Hanuere 2021. Kei runga ipurangi kei http://scientificeuropean.co.uk/covid-19/types-of-covid-19-vaccine-in-vogue-could-there-be-something-amiss/  
8. Soni R. 2021. Ake ake nei o Adenovirus based COVID-19 Vaccines (pēnei i a Oxford AstraZeneca) i runga i nga kitenga tata nei mo te Take o nga paanga taha onge o te toto toto. Pūtaiao Pākehā. I whakairihia i te 3 o Hakihea 2021. Kei runga ipurangi kei http://scientificeuropean.co.uk/covid-19/future-of-adenovirus-based-covid-19-vaccines-such-as-oxford-astrazeneca-in-light-of-recent-finding-about-cause-of-rare-side-effects-of-blood-clot/  

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