Ko te moe e pa ana ki te ahotea me te mate mahara he raru hauora nui kei te pa ki te tini o nga tangata. Ko te corticotropin-releasing hormone (CRH) neurons i roto i te paraventricular nucleus (PVN) i roto i te hypothalamus ka whai waahi nui ki te te teitei o nga taumata cortisol hei whakautu ki te ahotea engari Ko te ara neuronal kaore i te mohiotia. I roto i te rangahau tata nei mo nga kiore taiwhanga, i kitea e nga kairangahau ko te whakaongaonga o nga neuron homoni tuku corticotropin i roto i te paraventricular nucleus o te hypothalamus (CRH).PVN) i puta hoki te moe whakararu me te maharahara, he rite ki nga paanga i puta mai i te ahotea aukati, ara, te ahotea me te whakaihiihi o CRHPVN Ko nga neurons he rite tonu nga paanga kino ki te moe me te mahara. He rereke nga paanga ki te moe me te mahara, ara, i pai ake te moe me te mahara i te wa CRHPVN i aukatihia nga neurons. Ko nga kitenga e kii ana ko nga paanga kino o te ahotea ki te moe me te mahara ka whakatauhia e te CRHPVN nga huarahi neuronal. Mai i te aukati i te CRHPVN Ko nga neurons i te wa o te ahotea ka pai ake te moe me nga mahi mahara, e aro ana ki te CRHPVN Ko nga huarahi neuronal pea he rautaki pai mo te maimoatanga o te moe e pa ana ki te ahotea me te mate mahara.
ahotea Ko te ahua o te awangawanga me te awangawanga na nga ahuatanga uaua o te ao. He urupare maori e akiaki ana i a tatou ki te whakatika i nga take me nga whakatuma kei mua i a tatou. Ka wheako nga tangata katoa i te ahotea i etahi wa o te ao. Ka pa ki to tatou hauora me to tatou oranga ki te kore e whakahaeretia me te whakatika tika. Ko tetahi o nga paanga nui o te ahotea ko te whakararu i te moe me te mate mahara.
Ka whakautu to tatou tinana ki te ahotea ma te hanga cortisol, te "hormone taumaha." I roto i nga ahuatanga taumaha, ka huna e te hypothalamus te homone tuku corticotropin-releasing hormone (CRH) ka whakaihiihi i te repe pituitary ki te whakahiato corticotropin, adrenocorticotropic hormone (ACTH), hei waahanga o te hypothalamic-pituitary-adrenal. tuaka (Tuaka HPA). Ko te corticotropin e whakaohooho ana i te cortex adrenal ki te whakahiato me te tuku i nga corticosteroids, te nuinga o nga glucocorticoids. Ko te pikinga o te taumata cortisol e arai ana ki te whakararu i te tauira moe me nga rerekee o te manawataki circadian no reira ka puta nga mate moe e pa ana ki te ahotea. Ko te Hypothalamus he mahi nui i roto i tenei, ina koa ko nga neurons corticotropin-releasing hormone (CRH) i roto i te paraventricular nucleus (PVN) i roto i te hypothalamus. Heoi ano, kare e tino marama nga huarahi e puta ai te ahotea ki te moe me te mate mahara. Kua tirohia tenei e tetahi rangahau tata nei.
Ki te tirotiro he pehea te hono o te corticotropin-releasing hormone (CRH) i nga neurons i roto i te paraventricular nucleus (PVN) i roto i te hypothalamus ki te moe e pa ana ki te ahotea me te raruraru mahara, ka akiakihia e nga kairangahau te ahotea i roto i nga kiore taiwhanga ma te pupuri i a raatau i roto i te ngongo kirihou. Ko nga kiore kua raruraru i kitea kua raruraru te moe. I tohe ano ratou ki te mahara mokowhiti i te wa i whakamatauria i te ra i muri mai. Ko enei paanga o te ahotea ki te moe me te mahara i roto i nga kiore taiwhanga i runga i nga rarangi e tumanakohia ana. Ka tirotirohia e nga kairangahau mena he whakaihiihi o te corticotropin-releasing hormone secreting neurons i roto i te paraventricular nucleus (CRH).PVN) o te hypothalamus i puta nga paanga o te moe me te mahara ki nga kiore taiwhanga kore taumaha.
He mea whakamiharo, ko te whakahohe i nga neurons homoni tuku corticotropin i roto i te paraventricular nucleus o te hypothalamus (CRH).PVN) i puta hoki te moe whakararu me te maharahara, he rite ki nga paanga i puta mai i te ahotea aukati, ara, te ahotea me te whakaihiihi o CRHPVN Ko nga neurons he rite nga paanga ki te moe me te mahara. He rereke nga paanga ki te moe me te mahara, ara, i pai ake te moe me te mahara i te wa CRHPVN i aukatihia nga neurons.
Ko nga hua o runga ake nei e tohu ana ko nga paanga kino o te ahotea ki te moe me te mahara ka whakatauhia e te CRHPVN nga huarahi neuronal. He mea nui tenei. Mai i te aukati i te CRHPVN Ko nga neurons i te wa o te ahotea ka pai ake te moe me nga mahi mahara, te maimoatanga o te moe e pa ana ki te ahotea me nga mate mahara ma te aukati i te CRHPVN Ka taea pea nga huarahi neuronal a muri ake nei. Ko te whanaketanga o naianei he anga whakamua iti ki tera huarahi.
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Tohutoro:
- Wiest, A., et al 2025. Te mahi a nga neuron CRH hypothalamic ki te whakahaere i te paanga o te ahotea ki te mahara me te moe. Journal of Neuroscience. I whakaputaina i te 9 Pipiri 2025. DOI: https://doi.org/10.1523/JNEUROSCI.2146-24.2025
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 neurons in the paraventricular nucleus (PVN) in the hypothalamus play a pivotal role in elevation of cortisol levels in response to stress however neuronal pathway is unknown. In a recent study on laboratory mice, researchers found that stimulation of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus (CRHPVN) also produced disrupted sleep and impaired memory, similar to effects produced by the restraint stress, viz., both stress and stimulation of CRHPVN neurons produced same adverse effects on sleep and memory. Conversely, effects on sleep and memory were opposite, i.e., sleep and memory improved when CRHPVN neurons were blocked. The findings suggest that the adverse effects of stress on sleep and memory are regulated by CRHPVN neuronal pathways. Since inhibiting CRHPVN neurons during stress improves sleep and memory functions, targeting CRHPVN neuronal pathways may be a good strategy for treatment of stress-related sleep and memory disorders.){kind=link}